Transfer of the immunologically competent T-lymphocytes from a donor into host expression different MHC antigens can have severe consequences, causing a fatal syndrome known as graft versus host disease (GVH). The following table explores a ran model of GVH, it displays the minimum number of parental strain t- cells which cause fatal GVH in sevearl treatment groups of F1 hybrid off spring derived from mating of two MHC different strain, a and b.
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| Minimum number of A or B strain t- cells which cause lethal GVH in the AxB F1 106 |
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| Group | (A X B) F1 hosts age and treatment | Strain A T cells | Strain B t cells |
| 1 | Intreated new born F1 | 5 | 5 |
| 2 | Untreated adult f1 | 1000 | 1000 |
| 3 | Adult F1 given 300 rad irradiation or an anti – proliferative drug | 5 | 5 |
| 4 | Adult F1 immunized with 10 of the strain parental t – cells and then irradiated as in group 3 | 1000 | 5 |
| 5 | Adult F1 immunized with 107 a strain t- cells taken from donors that had previously been made tolerant to MHC of B, and then irradiated as in group 3. | 5 | 5 |
Give a mechanistic explanation for finding which is consistent with all the data. Describe your answer with reasoning.
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