Solution-Results of a free radioimmunoassay | Homework Help

Allison is a 32-year-old female with the following symptoms: dismal facial expression; droopy eyelids; swollen face and per orbital areas; thin, dry hair; dry, crusty skin; evidence of intellectual impairment; lethargy; a change of personality; bradycardia (59 b/min); blood pressure of 93/72; anemia (hematocrit 28); enlarged heart (upon radiological exam); constipation, and hypothermia. Plasma concentrations of total and free T4 and T3 include:


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3.1 µg/dL

0.15 ng/dL


0.5 ng/dL

0.02 ng/dL

Elevated TSH levels were seen from the results of a Free Radioimmunoassay (RIA) of peripheral blood. A TSH stimulation test did not increase the output of thyroid hormones from the thyroid gland.

  • What endocrine organ is involved in this situation?
  • Is this a primary or secondary disorder? Explain.
  • Describe the feedback loop involved. Signify if there is an increased or decreased TSH level.
  • List several defects or disorders that could cause these symptoms.
  • Would you expect to find a palpable goiter? Why?

Describe an appropriate treatment for this patient.


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