Case connections Analysis Assignment | Essay Help Services

Case connections are short scenarios or puzzles based on the information from the current unit of study. For the Unit 1 Case Connections assignment, you will choose two of the following four case connection problems and provide detailed written solutions. This assignment is submitted through SafeAssign, which is a plagiarism prevention tool that allows your instructor to check the originality of a homework submission. To earn full credit: You will need to describe why your chosen answer is correct while also discussing why the other answers are incorrect. References in AMA format are also required. Do not include the questions provided as part of your submission. If your assignment has a SafeAssign score of >50% your instructor may request that you resubmit your assignment or justify this level of percentage overlap. Scores of >50% raise concern over academic integrity.Unit 1 Case Connections
Description:
Case connections are short scenarios or puzzles based on the information from the current unit
of study.
For the Unit 1 Case Connections assignment, you will choose two of the following four case
connection problems and provide detailed written solutions. This assignment is submitted
through SafeAssign, which is a plagiarism prevention tool that allows your instructor to check
the originality of a homework submission.
To earn full credit:
1. You will need to describe why your chosen answer is correct while also discussing why
the other answers are incorrect.
2. References in AMA format are also required.
3. Do not include the questions provided as part of your submission.
4. If your assignment has a SafeAssign score of >50% your instructor may request that you
resubmit your assignment or justify this level of percentage overlap. Scores of >50%
raise concern over academic integrity.
Your assignment will be graded on your logic and accuracy as well as on the clarity and
organization of the overall assignment.
Submit your written assignment via the digital drop box.
Case 1:
Methotrexate works as an anticancer drug by competitively inhibiting the enzyme dihydrofolate
reductase. A set of experiments was done using 10 nM dihydrofolate reductase, a range of dihydrofolate
concentrations (1μM – 500 μM) and 0, 5 nM and 20 nM methotrexate. The initial rates of each of these
reactions were measured.
Which of the following figures shows the most likely outcome of these experiments? (Please be sure to
discuss why you choose your answer and why the other choices are incorrect).
UNE Online _ Case connections
Case 2:
A researcher was studying red blood cells from a patient homozygous for the sickle cell mutation in the
β-globin gene (βE6V). She found that increasing the concentration of one of the following chemicals
decreased the frequency of sickling by these cells.
What chemical is this most likely to be?
A. 2,3-Bisphosphoglycerate (BPG)
B. Fe2+
C. glucose
D. histidine
E. O2
UNE Online _ Case connections
Case 3:
A 15-year old girl with cystic fibrosis is rushed to the hospital for an acute respiratory infection and
suspected pneumonia. The admission chest x-ray showed extensive bronchiectasis and persistent
complete atelectasis in the lower left lobe. Despite aggressive therapy including IV antibiotics, the
patient’s pulmonary function remained poor and level of consciousness was diminished with no verbal
responses but eyes open to voice. Sputum samples were collected via airway suctioning, arterial blood
gasses were draw and pH was determined to be 7.32 (normal pH: 7.4).
As a radical therapy for this patient an infusion of fetal hemoglobin is suggested to potentially increase
oxygen perfusion. Fetal hemoglobin (HbF) has different oxygen binding kinetics when compared to the
oxygen binding displayed by adult hemoglobin (illustrated below). This difference is in part due to the
inability of HbF to interact with 2,3 bisphosphoglycerate (2,3 BPG).
Based on this information would the use of HbF as a potential therapy in this patient be successful?
Case 4:
A 57-year-old female is found unconscious in her home by emergency services. The woman’s neighbor
called the police as she had not seen her neighbor all day and they typically met for coffee around 10
am. The emergency services confirmed the presence of a carbon monoxide leak in the house from a
generator left running in her living room.
Based on this information, which of the following results is most reflective of this individual’s metabolic
state at time of presentation? (Please discuss the rationale for this answer; arrows indicate increase or
decrease when compared to an individual with a functional ETC)
UNE Online _ Case connections
Cytosolic NADH Mitochondrial NADH Oxygen consumption ATP production
A. ↑ ↓ ↓ ↓
B. ↑ ↑ ↓ ↓
C. ↑ ↓ ↓ ↑
D. ↓ ↑ ↑ ↑
E. ↓ ↓ ↑ ↑