Catalytic behavior of the isozymes of liver | Homework Help

The catalytic behavior of the isozymes of liver and brainphosphofructokinase-1 (PFK-1) was observed in the presence of AMP,phosphate, and fructose-2,6-bisphosphate. The table below shows theconcentration of each effector required to achieve 50% of Vmax. Compare the response of the two isozymes to the three effectors anIDiscuss the implications of their different responses.

Isozyme          Phosphate (µM)           AMP(µM)       F2,6P (µM)

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Liver              200                 10                  0.05

Brain              350                 75                  4.5

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